Novo Nordisk unveiled real-world findings from the SIGNAL and OCTANE studies at ObesityWeek 2026, demonstrating that Wegovy injection and oral semaglutide are associated with reductions in "food noise." The retrospective analyses, conducted via the Ro telehealth platform, showed significant decreases in intrusive thoughts about food among adults with obesity or overweight, marking an emerging area of research for the company.
Novo Nordisk presented real-world ObesityWeek 2026 data on Nov 14, 2026 showing semaglutide (Wegovy injection and oral) reduced food noise scores, e.g. ~25% reduction over 3 months in OCTANE (p<0.001). This supports the drug's patient-centered appeal but is retrospective, association-only evidence with self-reported data, and contains no revenue, guidance or comparable financial figure.
- • SIGNAL study: food noise score reduction of -0.42 points in month 1 and -0.72 points at 6 months in 26,213 adults
- • OCTANE study: ~25% reduction in oral semaglutide food noise scores over 3 months (2.8 to 2.1, p<0.001)
- • Real-world studies show associations only and cannot determine causality
- • Self-reported data, selection bias from treatment persistence, limited generalizability